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Depakote DR(Divalproex)

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Depakote DR

Category: Anticonvulsants

Brand: Depakote DR

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Depakote DR 250mg x 30 pills

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Depakote DR is an anticonvulsant that is used to control seizures and migraine headaches. Take this medicine at the same time regularly. Do not take this medicine if you are suffering from an impaired liver function.

Active Ingredient:

Divalproex

Uses of Depakote DR

Depakote DR is used in the treatment of epilepsy, is a brain disorder that causes repeated seizures. Uncontrolled jerking movements and loss of consciousness are some of the symptoms of epilepsy.

Depakote DR is used in the treatment of mania, which is a mental disorder characterized by hyperactivity and racing thoughts.

This medication is also used for prophylaxis of migraine headaches characterized by severe headache, eye pain, nausea, and vomiting.

Highlights

The peak effect of this medicine can be observed in 2 hours.

The effect of this medicine lasts for an average of 1 to 2 days.

Consumption of alcohol with this medicine is not recommended as it increases the risk of side effects like dizziness, difficulty in concentration. Do not perform activities that require mental alertness like driving or operating machinery.

No habit-forming tendency has been reported.

This medicine is not recommended for pregnant women.

Depakote DR may be taken by nursing mothers only if needed, and no safer alternative is available. Monitoring of undesired effects like discoloration of eyes and skin is necessary.

General instructions

Take Depakote DR with or without food. Do not take in larger amounts than advised. Inform the doctor if you experience any undesirable effects. Do not stop taking the medicine without consulting your doctor as it may cause seizures.

Missed dose

If you miss a dose of Depakote DR, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.

How it works

It works by binding to the receptors in the brain and inhibits the excitation of brain cells.

Side effects

The following adverse reactions may occur while using this medication:

  • Diarrhea (severe)
  • Confusion (severe)
  • Headache (severe)
  • Muscle pain (severe)
  • Unusual tiredness and weakness (severe)
  • Sleepiness (severe)
  • Anxiety (severe)
  • Blurred vision (severe)
  • Yellow colored eyes or skin (severe)
  • Weight gain (severe)
  • Acid or sour stomach
  • Skin rash
  • Forgetfulness
  • Irregular menstrual periods
  • Ear pain
When not to use?

Do not take this medicine if you have a known allergy to its active ingredient Divalproex or any other components of Depakote DR.

Do not use this medication if you have any liver injury or a family history of liver injury.

Do not give this medicine to patients with urea cycle disorder (high ammonium levels in the blood) or a family history of urea cycle disorder.

Depakote DR is not for use in patients with a suspected mitochondrial disorder (e.g., Alpers-Huttenlocher syndrome).

Drug interactions

Depression (severe)

  • Depakote DR should be given with caution in patients with depression and suicidal thoughts. Frequent monitoring of depression symptoms is necessary. Dose adjustments are to be made based on the outcomes in the patient.

Liver disease (severe)

  • Depakote DR is not recommended in patients with liver injury or a family history of liver injury. This risk is more in children less than 2 years of age. Liver function tests are to be performed before starting the treatment. Discontinue the medicine if any abnormality is identified.
Warnings

  • Pancreatitis. Depakote DR may cause pancreatitis, which is a serious life-threatening reaction. Discontinue the medicine if pancreatitis is detected; alternative medicine should be considered in this case.
  • Bleeding disorder. Use with caution in patients with a bleeding disorder as it may cause thrombocytopenia. Make necessary dosage adjustments or discontinue the medicine if this condition is identified.
  • Suicidal behavior. Depakote DR may increase the risk of suicidal thoughts. It should be used with caution, and the prescription size should be limited in patients with depression or suicidal tendencies.
  • Pediatric use. Depakote DR is not recommended in children less than 2 years of age due to the increased risk of liver injury.
  • Geriatric use. Use with caution in the elderly population as it may lead to dizziness. The safety and efficacy of this medicine in the prophylaxis of migraines is not established.
  • Impaired liver function. This medicine is not recommended in patients with liver injury or a family history of liver injury.
  • Impaired kidney function. Use with caution in patients with a kidney injury. Suitable dose adjustments are to be made based on the clinical condition.
  • Pregnancy. This medicine is not recommended for pregnant women.
  • Breastfeeding. This medicine is recommended only if needed when no safer alternative is available. Monitoring of undesired effects like discoloration of eyes and skin is necessary.
Interaction with alcohol

Use of Anticonvulsants with alcohol will increase the central nervous system and respiratory system depression. Consumption of alcohol with this medicine is not recommended as it increases the risk of side effects like dizziness, difficulty in concentration. Do not perform activities that require mental alertness like driving or operating machinery.

Drug interactions

Some of the medicines may come into interaction with Depakote DR, particularly:

  • Lamotrigine (severe)
  • Metoclopramide (moderate)
  • Warfarin (moderate)
  • Ethinyl Estradiol (moderate)
  • Imipenem (severe)

This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

Q: Is it safe with alcohol?

A: Consumption of alcohol with this medicine is not recommended as it increases the risk of side effects like dizziness, difficulty in concentration. Do not perform activities that require mental alertness like driving or operating machinery.

Q: Is it habit forming?

A: No habit-forming tendency has been reported.

Q: Usage in pregnancy?

A: This medicine is not recommended for pregnant women.

Q: Usage while breastfeeding?

A: This medicine is recommended only if needed when no safer alternative is available. Monitoring of undesired effects like discoloration of eyes and skin is necessary.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide Shipping

Worldwide Shipping

Registered Mail  Not trackable 14-21 business days USD 15.00 per order
EMS  Trackable, where available 5-9 business days USD 25.00 per order

Delivery time is:

Registered Mail - 14-21 business days, price - USD 15.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 25.00, signature is required on delivery.
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